As I get started with this blog I am reminded that many people have not heard of ACell or extracellular matrix or even regenerative medicine, but that will be the purpose of this blog; to inform, to educate and to listen to your feedback. We can help dogs that are being considered for euthanasia.
Starting at the beginning when Jim D and I first learned of the research being conducted by Steve Badylak, DVM, PhD, MD and Alan Spievack, MD, we knew that we had found something of great value. Their research with extracellular matrices was showing great promise in the lab. It was Dr. Spievack who was focused on the basement membrane and hence the discovery of UBM. (Urinary bladder matrix). Since then, over 10 years ago now, many scientific papers have been published studying various applications of this technology and its basic science. More recently the technology has been introduced to the marketplace and is being used daily in human medicine and in Veterinary medicine for a wide variety of applications.
Extracellular matrix is present in all species. It is the soup that cells live in. It is comprised of different types of collagens, growth factors, glycosaminoglycans, glycoproteins and many other beneficial components that support healthy cellular growth and helps direct the cellular level information highway. It is not hard to understand then, that when this material, void of cells, is put into the body, that the body knows what to do with it. It contains the information to stimulate angiogenesis (new blood vessel formation) which leads to recruitment of new cells, even stem cells, which can populate the 3 dimensional scaffold and with the appropriate stressors, make new site specific tissue.
Simplifying all this, UBM has the ability to help heal deficient tissues or damaged tissue.
So why would I pick Osteoarthritis in dogs to start the discussion? The answer is simple if you have watched severely arthritic dogs try to go about the daily business of being a dog. This product in its powdered form is mixed with saline and injected into arthritic hips. The first few days after the injection will be no better, but then most dogs improve dramatically and the improvement may last for six months or longer. You can actually view the procedure on our website at www.acellvet.com.
We don't have all the answers scientifically why this works, but for severely arthritic dogs isn't worth a try?
I look forward to your comments.....